05). CONCLUSIONS Undergraduate students were generally not aware of LGBT resources in Dutch dental schools. This lack of knowledge calls for attention by dental school administrators, program directors, and faculty to foster a visible, comprehensive, culturally competent environment in dental education settings in The Netherlands. © 2020 American Dental Education Association.INTRODUCTION The National Blood Collection and Utilization Survey (NBCUS) has demonstrated declines in blood collection and transfusion in the United States since 2008, including declines of 11.6% in red blood cell (RBC) collections and 13.9% in RBC transfusions during 2013-2015. This study described the 2017 NBCUS results. METHODS The 2017 NBCUS was distributed to all US blood collection centers, all hospitals performing at least 1000 surgeries annually, and a 40% random sample of hospitals performing 100 to 999 surgeries annually. Weighting and imputation were used to generate national estimates for units of blood and components collected, deferred, distributed, transfused, and outdated. RESULTS Response rates for the 2017 NBCUS were 88% for blood collection centers and 86% for transfusing hospitals. Compared with 2015, the number of RBC units collected during 2017 (12,211,000; 95% confidence interval [CI], 11,680,000-12,742,000) declined by 3.0%, and transfused RBC units (10,654,000, 95% CI, 10,314,000-10,995,000) declined by 6.1%. Distributed platelet (PLT) units (2,560,000; 95% CI, 2,391,000-2,730,000?units) increased by 5.1%, and transfused PLT units (1,937,000, 95% CI, 1,794,000-2,079,000) declined by 2.3%. Distributed plasma units (3,209,000; 95% CI, 2,879,000-3,539,000) declined by 13.6%, and transfused plasma units (2,374,000; 95% CI, 2,262,000-2,487,000) declined by 12.9%. CONCLUSION The 2017 NBCUS suggests a continued but slowing decline in demand for RBCs. The decline in blood collection and use will likely continue. Despite decreasing demand and increasing manufacturing costs of blood products, the US blood industry has met the regular and emergent needs of the country. Published 2019. This article is a U.S. Government work and is in the public domain in the USA.Recent advances in sequencing technologies have allowed for the identification of recurrent mutations in acute myeloid leukaemia (AML). The transcription factor CCAAT&nbsp;enhancer&nbsp;binding protein alpha (CEBPA) is frequently mutated in AML, and biallelic CEBPA-mutant AML was recognised as a separate disease entity in the recent World Health Organization classification. However, CEBPA mutations are co-occurring with other aberrations in AML, and together these lesions form the clonal hierarchy that comprises the leukaemia in the patient. Here, we aim to review the current understanding of co-occurring mutations in CEBPA-mutated AML and their implications for disease biology and clinical outcome. We will put emphasis on patterns of cooperation, how these lesions cooperate with CEBPA mutations and the underlying potential molecular mechanisms. Finally, we will relate this to patient outcome and future options for personalised medicine. © 2020 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley &amp; Sons Ltd.We previously reported a protective association between single nucleotide polymorphisms (SNPs; rs4415345G and rs4610776A alleles) of Paneth cell α-defensin-5 against acute graft-versus-host disease (aGVHD). Because dysbiosis has been associated with aGVHD, we hypothesized that these SNPs may have a gut microbiota signature. In Lasso regression analysis of 248 healthy individuals, rs4415345G was associated with a higher abundance of Odoribacter splanchnicus, an anaerobic butyrogenic commensal. In multivariable analysis of data from 613 allogeneic haematopoietic cell transplant recipients, peri-engraftment presence of O.&nbsp;splanchnicus was associated with ~50% lower risk for grade II-IV aGVHD (hazard ratio 0?53, 95% confidence interval 0?28-1?00, P&nbsp;=&nbsp;0?05). O.&nbsp;splanchnicus may protect rs4415345G individuals against aGVHD. https://www.selleckchem.com/products/mlt-748.html © 2020 British Society for Haematology and John Wiley &amp; Sons Ltd.BACKGROUND Investigating the effect of N-(2-chloro-4-pyridyl)-N'-phenylurea (CPPU) on the bulk optical properties of postharvest kiwifruit is helpful in understanding the mechanism of identification of CPPU-treated kiwifruit using spectroscopy and to develop effective optical sensing techniques. In this study, the absorption coefficient μa and reduced scattering coefficient μ s ' of flesh and skin of kiwifruit treated with CPPU solutions at CPPU concentration levels (CCLs) of 0, 5, 10 and 15?mg?L-1 were measured by using a single integrating sphere setup over the range 950-1650?nm during 12?weeks' storage. RESULTS Generally, at the same storage period, there was no significant difference (P???0.05) on flesh's μa among the kiwifruit treated with different CCLs at absorption peaks of 970, 1190, and 1390?nm. The average flesh's μ s ' of kiwifruit treated with higher CCLs at 1190?nm were larger than those treated with lower CCLs, and there was a significant difference (P???0.05) between the kiwifruit treated with 0, 5 and 15?mg?L-1 CPPU solutions except for week 6. Contrasted with the μa and μ s ' of kiwifruit flesh, the μa and μ s ' of skin had bigger standard deviations and larger fluctuations with storage time. Additionally, the CPPU-treated kiwifruit had higher moisture content, lower firmness, and larger cells than CPPU-untreated kiwifruit. CONCLUSIONS This study indicates that the μ s ' of flesh has potential in identifying kiwifruit treated with different CCLs during storage. © 2020 Society of Chemical Industry. © 2020 Society of Chemical Industry.The content of protein components of glutinous rice significantly affects the quality of Chinese rice wine. Therefore, the effects of protein components on the quality of Chinese rice wine were studied by adding the exogenous proteins glutelin and albumin individually or in combination RESULTS Compared with the control, the samples with increased glutelin components exhibited improved formation of numerous alcohol esters with alcoholic and fruity representatives. The promotion rates of glutelin to total alcohols and total esters were 18% and 99%, respectively. The amount of 4-vinylguaiacol characterized by a spicy, smoky odor was reduced to 40%. Correlation analysis between chemical composition and sensory characteristics showed a significant positive correlation between umami and amino nitrogen (r=0.935) and total amino acid content (r=0.729). The bitterness of Chinese rice wine was related to the change of alcohol content (r=0.689) and total soluble solid (r=0.904). Sensory analysis revealed that the increase of the glutelin component of Chinese rice wine increased its alcoholic, fruity, and honey-like features, as well as its umami, acidity, and bitterness.